Genome-enabled discovery of anthraquinone biosynthesis in Senna tora.
Nat Commun
; 11(1): 5875, 2020 11 18.
Article
em En
| MEDLINE
| ID: mdl-33208749
ABSTRACT
Senna tora is a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains a mystery. To identify the genes responsible for plant anthraquinone biosynthesis, we reveal the genome sequence of S. tora at the chromosome level with 526 Mb (96%) assembled into 13 chromosomes. Comparison among related plant species shows that a chalcone synthase-like (CHS-L) gene family has lineage-specifically and rapidly expanded in S. tora. Combining genomics, transcriptomics, metabolomics, and biochemistry, we identify a CHS-L gene contributing to the biosynthesis of anthraquinones. The S. tora reference genome will accelerate the discovery of biologically active anthraquinone biosynthesis pathways in medicinal plants.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Plantas
/
Antraquinonas
/
Genoma de Planta
/
Senna
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article