Variance-based sensitivity analysis for uncertainties in proton therapy: A framework to assess the effect of simultaneous uncertainties in range, positioning, and RBE model predictions on RBE-weighted dose distributions.

Hofmaier, Jan; Dedes, George; Carlson, David J; Parodi, Katia; Belka, Claus; Kamp, Florian

Hofmaier, Jan; Dedes, George; Carlson, David J; Parodi, Katia; Belka, Claus; Kamp, Florian.

Afiliação

Hofmaier J; Department of Radiation Oncology, University Hospital, LMU Munich, Munich, 81377, Germany.
Dedes G; Department of Medical Physics, Faculty of Physics, LMU Munich, Garching b. Munich, 85748, Germany.
Carlson DJ; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Parodi K; Department of Medical Physics, Faculty of Physics, LMU Munich, Garching b. Munich, 85748, Germany.
Belka C; Department of Radiation Oncology, University Hospital, LMU Munich, Munich, 81377, Germany.
Kamp F; German Cancer Consortium (DKTK), Munich, 81377, Germany.

Med Phys ; 48(2): 805-818, 2021 Feb.

Article em En | MEDLINE | ID: mdl-33210739

Assuntos

Terapia com Prótons; Análise de Variância; Humanos; Masculino; Planejamento da Radioterapia Assistida por Computador; Eficiência Biológica Relativa; Incerteza

Palavras-chave

proton therapy; range uncertainty; relative biological effectiveness; sensitivity analysis; uncertainty analysis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia com Prótons Tipo de estudo: Diagnostic_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Limite: Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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