Bicyclic Piperidines via [2 + 2] Photocycloaddition.
J Org Chem
; 86(3): 2200-2209, 2021 02 05.
Article
em En
| MEDLINE
| ID: mdl-33211487
ABSTRACT
A synthetic strategy to fused bicyclic piperidines-building blocks for medicinal chemistry-is developed. The key step was an intramolecular [2 + 2]-photocyclization. The photochemical step was performed on a gram scale. Crystallographic analysis of the obtained compounds revealed that they occupy a novel chemical space and can be considered as elongated analogues of 3-substituted piperidines.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Química Farmacêutica
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article