Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase".
Science
; 370(6519)2020 11 20.
Article
em En
| MEDLINE
| ID: mdl-33214251
ABSTRACT
Hadzipasic et al (Reports, 21 February 2020, p. 912) used ancestral sequence reconstruction to identify historical sequence substitutions that putatively caused Aurora kinases to evolve allosteric regulation. We show that their results arise from using an implausible phylogeny and sparse sequence sampling. Addressing either problem reverses their inferences Allostery and the amino acids that confer it were not gained during the diversification of eukaryotes but were lost in a subgroup of Fungi.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aurora Quinases
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article