(-)-Camphene-based derivatives as potential antibacterial agents against Staphylococcus aureus and Enterococcus spp.
Future Microbiol
; 15: 1527-1534, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-33215538
ABSTRACT
Aim:
To evaluate the activity of (-)-camphene-based thiosemicarbazide (TSC) and 4-hydroxy-thiosemicarbazone (4-OH-TSZ), alone and in combination against Gram-positive. Material &methods:
MIC were determined for Staphylococcus aureus, Enterococcus spp. reference strains and clinical isolates. Drug combination, time-kill and cytotoxicity assays were also performed.Results:
TSC and 4-OH-TSZ demonstrated potent inhibitory activity against S. aureus and Enterococcus spp., including multidrug-resistant isolates (MIC ranging from 1.9 to 31.2 µg/ml), and were bactericidal for the reference strains of both Gram-positive tested. The derivatives proved to be selective for the bacteria and synergistic with oxacillin and vancomycin.Conclusion:
(-)-Camphene-based derivatives can represent promising drug candidates against critical pathogens, such as S. aureus and Enterococcus spp., including MRSA and vancomycin resistance Enterococcus spp. isolates.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
/
Tiossemicarbazonas
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Enterococcus
/
Monoterpenos Bicíclicos
/
Antibacterianos
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article