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A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
Picado, Alfredo; Chaikuad, Apirat; Wells, Carrow I; Shrestha, Safal; Zuercher, William J; Pickett, Julie E; Kwarcinski, Frank E; Sinha, Parvathi; de Silva, Chandi S; Zutshi, Reena; Liu, Shubin; Kannan, Natarajan; Knapp, Stefan; Drewry, David H; Willson, Timothy M.
Afiliação
  • Picado A; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7264, United States.
  • Chaikuad A; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Straße 9, Frankfurt 60438, Germany.
  • Wells CI; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences (BMLS), Max-von-Laue-Straße 15, Frankfurt 60438, Germany.
  • Shrestha S; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7264, United States.
  • Zuercher WJ; Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602, United States.
  • Pickett JE; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7264, United States.
  • Kwarcinski FE; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7264, United States.
  • Sinha P; Luceome Biotechnologies, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States.
  • de Silva CS; Luceome Biotechnologies, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States.
  • Zutshi R; Luceome Biotechnologies, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States.
  • Liu S; Luceome Biotechnologies, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States.
  • Kannan N; Research Computing Center, University of North Carolina, Chapel Hill, North Carolina 27599-3420, United States.
  • Knapp S; Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602, United States.
  • Drewry DH; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.
  • Willson TM; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Straße 9, Frankfurt 60438, Germany.
J Med Chem ; 63(23): 14626-14646, 2020 12 10.
Article em En | MEDLINE | ID: mdl-33215924
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Tiofenos / Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases / Proteínas Reguladoras de Apoptose Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Tiofenos / Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases / Proteínas Reguladoras de Apoptose Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article