Effect of diarrhoea on Tacrolimus trough level in a post liver transplant patient.
Med J Malaysia
; 75(6): 734-735, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-33219186
ABSTRACT
Tacrolimus, which bonds to an immunophilin, FK506 binding protein (FKBP) has emerged as one of the most widely used immunosuppressant post solid organ transplantation. It offers excellent patient survival rates post-transplantation and a lesser number of acute rejections as compared to cyclosporine. Tacrolimus has a narrow therapeutic window with overexposure leading to acute and chronic forms of nephrotoxicity. Remarkably few data have been published on the overexposure to tacrolimus following mild diarrhoea in post-transplant patients who received treatment with tacrolimus. We observed a post-liver transplant patient with increased trough level of tacrolimus during severe diarrhoea with no complications following a timely adjustment on the dose of tacrolimus.
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Órgãos
/
Transplante de Fígado
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article