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Development of programmable gemcitabine-GnRH pro-drugs bearing linker controllable "click" oxime bond tethers and preclinical evaluation against prostate cancer.
Vrettos, Eirinaios I; Karampelas, Theodoros; Sayyad, Nisar; Kougioumtzi, Anastasia; Syed, Nelofer; Crook, Timothy; Murphy, Carol; Tamvakopoulos, Constantin; Tzakos, Andreas G.
Afiliação
  • Vrettos EI; Department of Chemistry, University of Ioannina, Ioannina, GR-45110, Greece.
  • Karampelas T; Division of Pharmacology-Pharmacotechnology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation ofthe Academy of Athens, Athens, Greece.
  • Sayyad N; Department of Chemistry, University of Ioannina, Ioannina, GR-45110, Greece.
  • Kougioumtzi A; Department of Biomedical Research, Institute of Molecular Biology and Biotechnology - Forth, Ioannina, Greece.
  • Syed N; John Fulcher Neuro-oncology Laboratory, Dept of Brain Sciences, Division of Neuroscience, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.
  • Crook T; John Fulcher Neuro-oncology Laboratory, Dept of Brain Sciences, Division of Neuroscience, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.
  • Murphy C; Department of Biomedical Research, Institute of Molecular Biology and Biotechnology - Forth, Ioannina, Greece.
  • Tamvakopoulos C; Division of Pharmacology-Pharmacotechnology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation ofthe Academy of Athens, Athens, Greece.
  • Tzakos AG; Department of Chemistry, University of Ioannina, Ioannina, GR-45110, Greece; University Research Center of Ioannina (URCI), Institute of Materials Science and Computing, Ioannina, Greece. Electronic address: atzakos@uoi.gr.
Eur J Med Chem ; 211: 113018, 2021 Feb 05.
Article em En | MEDLINE | ID: mdl-33223264
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oximas / Neoplasias da Próstata / Pró-Fármacos / Hormônio Liberador de Gonadotropina / Receptores LHRH / Desoxicitidina Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oximas / Neoplasias da Próstata / Pró-Fármacos / Hormônio Liberador de Gonadotropina / Receptores LHRH / Desoxicitidina Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article