Your browser doesn't support javascript.
loading
The Tailgate Study: Differing metabolic effects of a bout of excessive eating and drinking.
Syed-Abdul, Majid M; Jacome-Sosa, Miriam; Hu, Qiong; Gaballah, Ayman H; Winn, Nathan C; Lee, Nhan T; Mucinski, Justine M; Manrique-Acevedo, Camila; Lastra, Guido; Anderson, Jennifer M; Al Juboori, Alhareth; Bartholow, Bruce D; Parks, Elizabeth J.
Afiliação
  • Syed-Abdul MM; Department of Nutrition and Exercise Physiology, School of Medicine, University of Missouri, Columbia, MO, United States.
  • Jacome-Sosa M; Department of Nutrition and Exercise Physiology, School of Medicine, University of Missouri, Columbia, MO, United States.
  • Hu Q; Department of Nutrition and Exercise Physiology, School of Medicine, University of Missouri, Columbia, MO, United States.
  • Gaballah AH; Department of Radiology, School of Medicine, University of Missouri, Columbia, MO, United States.
  • Winn NC; Department of Nutrition and Exercise Physiology, School of Medicine, University of Missouri, Columbia, MO, United States.
  • Lee NT; Department of Nutrition and Exercise Physiology, School of Medicine, University of Missouri, Columbia, MO, United States.
  • Mucinski JM; Department of Nutrition and Exercise Physiology, School of Medicine, University of Missouri, Columbia, MO, United States.
  • Manrique-Acevedo C; Department of Medicine, Division of Endocrinology, School of Medicine, University of Missouri, Columbia, MO, United States.
  • Lastra G; Department of Medicine, Division of Endocrinology, School of Medicine, University of Missouri, Columbia, MO, United States.
  • Anderson JM; Department of Nutrition and Exercise Physiology, School of Medicine, University of Missouri, Columbia, MO, United States.
  • Al Juboori A; Department of Medicine, Division of Gastroenterology and Hepatology, School of Medicine, University of Missouri, Columbia, MO, United States.
  • Bartholow BD; The College of Arts and Science, Department of Psychological Sciences, University of Missouri, Columbia, MO, United States.
  • Parks EJ; Department of Nutrition and Exercise Physiology, School of Medicine, University of Missouri, Columbia, MO, United States; Department of Medicine, Division of Gastroenterology and Hepatology, School of Medicine, University of Missouri, Columbia, MO, United States. Electronic address: parksej@missouri
Alcohol ; 90: 45-55, 2021 02.
Article em En | MEDLINE | ID: mdl-33232792
ABSTRACT

INTRODUCTION:

Excess energy intake by spectators at a sporting event (i.e., a tailgate) might cause acute negative health effects. However, limited data exist regarding the effects of overeating and alcohol consumption on lipid metabolism and the potential to gain intrahepatic triacylglycerols (IHTG). We tested the hypothesis that overconsumption of food and alcohol would significantly increase both hepatic de novo lipogenesis (DNL) and IHTG.

METHODS:

Eighteen males (mean ± SD, age 31.4 ± 7.3 years, BMI 32.1 ± 5.9 kg/m2) were given alcoholic drinks to elevate blood alcohol for 5 h, while highly palatable food was presented. Blood samples were collected and DNL in TG-rich lipoproteins (TRL) was measured by GC/MS, IHTG was measured via MRS (n = 15), and substrate oxidation was measured via indirect calorimetry.

RESULTS:

Subjects consumed 5087 ± 149 kcal (191 ± 25% excess of total daily energy needs including 171 ± 24 g alcohol), which increased plasma insulin, glucose, TG, and decreased NEFA (ANOVA p ≤ 0.003 for all). Both DNL and TRL-TG increased (p < 0.001), while IHTG did not change in the group as a whole (p = 0.229). Individual subject data revealed remarkably differing responses for IHTG (nine increased, five decreased, one did not change). Despite maintaining equal breath alcohol levels, subjects with IHTG elevations exhibited higher DNL, consumed 90% less alcohol (p = 0.048), tended to consume more carbohydrates, and exhibited lower whole-body fat oxidation (not significant) compared to those whose IHTG was reduced.

DISCUSSION:

This study demonstrates that acute excess energy intake may have differing effects on an individual's DNL and IHTG, and dietary carbohydrate may influence DNL more than alcohol.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Consumo de Bebidas Alcoólicas / Carboidratos da Dieta / Hiperfagia / Metabolismo dos Lipídeos Limite: Adult / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Consumo de Bebidas Alcoólicas / Carboidratos da Dieta / Hiperfagia / Metabolismo dos Lipídeos Limite: Adult / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article