Management of Pulmonary Arterial Hypertension Patients with World Health Organization Functional Class II.
Acta Cardiol Sin
; 36(6): 583-587, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-33235413
Pulmonary arterial hypertension (PAH) is an incurable chronic and progressive debilitating disease associated with significant morbidity and mortality. The World Health Organization functional class (WHO FC) at diagnosis and at follow-up remains one of the strongest predictors of survival in PAH. Studies have shown improved long-term outcomes in PAH patients who received PAH-specific treatment, as monotherapy or as combination therapy, early in their disease course. Studies have also shown that without treatment, PAH rapidly deteriorates even in patients with less advanced (low risk) disease state. In this article, we review evidence from randomized controlled clinical trials to support our position on the importance of early PAH management in WHO FC II patients. The growing importance of combination therapy in the early treatment of PAH and recommendations by the most recent guidelines for the diagnosis and treatment of pulmonary hypertension are also discussed in this article.
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Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
/
Guideline
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Prognostic_studies
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article