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Antifungal potential of extracts, fractions and compounds from Uvaria comperei (Annonaceae) and Oxyanthus unilocularis (Rubiaceae).
Kayo, Maurice Taboula; Simo, Marguerite Kamdem; Tagatsing Fotsing, Maurice; Talla, Emmanuel; Laurent, Sophie; Elst, Luce Vander; Henoumont, Céline; Yankep, Emmanuel; Alfred Ngenge, Tamfu; Keumoe, Rodrigue; Atchade, Alex de Theodore; Zeukóo, Elisabeth Menkem; Sameza, Modeste Lambert; Roch, Alain; Muller, Robert; Boyom, Fabrice Fekam; Mbafor, Joseph Tanyi.
Afiliação
  • Kayo MT; Laboratory No. 3 of Organic Chemistry, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
  • Simo MK; Department of Chemistry, Higher Teacher Training College, University of Bamenda, Bambili, Cameroon.
  • Tagatsing Fotsing M; Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
  • Talla E; Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua, Cameroon.
  • Laurent S; Laboratory No. 3 of Organic Chemistry, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
  • Elst LV; Department of Materials Engineering/Chemical Engineering, School of Chemical Engineering and Mineral Industries, University of Ngaoundéré, Ngaoundéré, Cameroon.
  • Henoumont C; NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, Faculty of Medicine and Pharmacy, University of Mons, Mons, Belgium.
  • Yankep E; NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, Faculty of Medicine and Pharmacy, University of Mons, Mons, Belgium.
  • Alfred Ngenge T; NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, Faculty of Medicine and Pharmacy, University of Mons, Mons, Belgium.
  • Keumoe R; Laboratory No. 3 of Organic Chemistry, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
  • Atchade AT; Department of Materials Engineering/Chemical Engineering, School of Chemical Engineering and Mineral Industries, University of Ngaoundéré, Ngaoundéré, Cameroon.
  • Zeukóo EM; Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
  • Sameza ML; Laboratory No. 3 of Organic Chemistry, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
  • Roch A; Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
  • Muller R; Department of Biochemistry, Faculty of Science, University of Douala, Douala, Cameroon.
  • Boyom FF; NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, Faculty of Medicine and Pharmacy, University of Mons, Mons, Belgium.
  • Mbafor JT; NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, Faculty of Medicine and Pharmacy, University of Mons, Mons, Belgium.
Nat Prod Res ; 35(24): 5732-5736, 2021 Dec.
Article em En | MEDLINE | ID: mdl-33244992
ABSTRACT
Phytochemical study of Uvaria comperei afforded an alkaloid, 8,9-dimethoxy-5H-phenanthridin-6-one (1), isolated and characterised (assignment of 1H and 13C NMR) for the first time from a natural source along with two flavonoids, (2S)-5-hydroxy-7,8-dimethoxyflavanone (2) and (2S)-7-hydroxy-5-methoxy-6,8-dimethylflavone (3). Clethric acid (4), oleanoic acid (5), ß-sitosterol 3-O-ß-D-glucopyranoside (9), ß-sitosterol palmitate (6) and a mixture of stigmasterol (7) and ß-sitosterol (8) were isolated from Oxyanthus unilocularis. The structures of these compounds were elucidated using modern spectroscopic techniques including1D and 2D Nuclear Magnetic Resonance (NMR) Spectroscopy (1H, 13C, 1H-1H COSY, HSQC, HMBC) and Mass Spectrometry. Some fractions and compounds from Uvaria comperei exhibited good antifungal activity against clinical isolates and standard strains of yeast species of Candida and Cryptococcus genera while extracts from Oxyanthus unilocularis displayed weak antifungal activity. The results obtained show that Uvaria comperei could be a potential source of antifungal drugs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rubiaceae / Annonaceae / Uvaria Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rubiaceae / Annonaceae / Uvaria Idioma: En Ano de publicação: 2021 Tipo de documento: Article