fT3:fT4 ratio in Graves' disease - correlation with TRAb level, goiter size and age of onset.
Folia Med Cracov
; 60(2): 15-27, 2020 09 28.
Article
em En
| MEDLINE
| ID: mdl-33252592
ABSTRACT
INTRODUCTION:
Graves' Disease (GD) is an autoimmune hyperthyroidism occurring mostly in young women. The main pathogenic role of the disease is attributed to TSH receptor antibodies (TRAb), which stimulate the thyroid gland to increase production of the most active thyroid hormone- triiodothyronine (T3). High level of TRAb and a large goiter size are commonly known as poor prognostic factors for the disease and are used to predict relapse. THEAIM:
The purpose of our study was to check the correlation between fT3fT4 ratio with TRAb concentration, total volume of thyroid and age of GD onset. MATERIALS ANDMETHODS:
114 patients with onset or relapse of GD were analyzed. Those after thyroidectomy or radioiodine therapy were not taken into analysis. The data was retrospectively retrieved from the hospital's records consisting of patients' sex, age, level of TRAb, fT3, fT4 and thyroid volume on ultrasonography. The association between fT3fT4 and TRAb concentration, thyroid volume and age was evaluated using Pearson correlation coefficient.RESULTS:
The group was predominated by women (19.3% men, 80.7% women). The average age was 47.0. The analysis revealed positive correlation between 1) fT3fT4 ratio and total volume of thyroid (correlation ratio 0.37; p <0.05) 2) fT3fT4 ratio and level of TRAb (correlation ratio 0.26; p or <0.05) 3) negative correlation between fT3fT4 ratio and patient's age (correlation ratio -0.14; p = 0.144).CONCLUSIONS:
Positive correlations between fT3fT4 ratio and TRAb level and total volume of thyroid (poor predictors of GD) may confirm that high level of fT3 can also be a prognostic factor for GD severity.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glândula Tireoide
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Doença de Graves
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Imunoglobulinas Estimuladoras da Glândula Tireoide
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Bócio Subesternal
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article