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A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Wei, Spencer C; Meijers, Wouter C; Axelrod, Margaret L; Anang, Nana-Ama A S; Screever, Elles M; Wescott, Elizabeth C; Johnson, Douglas B; Whitley, Elizabeth; Lehmann, Lorenz; Courand, Pierre-Yves; Mancuso, James J; Himmel, Lauren E; Lebrun-Vignes, Benedicte; Wleklinski, Matthew J; Knollmann, Bjorn C; Srinivasan, Jayashree; Li, Yu; Atolagbe, Oluwatomisin T; Rao, Xiayu; Zhao, Yang; Wang, Jing; Ehrlich, Lauren I R; Sharma, Padmanee; Salem, Joe-Elie; Balko, Justin M; Moslehi, Javid J; Allison, James P.
Afiliação
  • Wei SC; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas. jallison@mdanderson.org spencer.wei@gmail.com javid.moslehi@vumc.org.
  • Meijers WC; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Axelrod ML; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Anang NAS; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Screever EM; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Wescott EC; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Johnson DB; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Whitley E; Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Lehmann L; Department of Cardiology, University Hospital of Heidelberg, Heidelberg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, German Research Center (DKFZ), Heidelberg, Germany.
  • Courand PY; Hospices Civils de Lyon, Service de cardiologie, IMMUCARE, Hôpital de la Croix-Rousse et Hôpital Lyon Sud, Lyon, France; Université de Lyon, CREATIS UMR INSERM U1044, INSA, Lyon France.
  • Mancuso JJ; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Himmel LE; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Lebrun-Vignes B; Department of Pharmacology, APHP. Sorbonne Université, INSERM, CIC-1901, UNICO-GRECO Cardiooncology Program, Paris, France.
  • Wleklinski MJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Knollmann BC; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Srinivasan J; Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas.
  • Li Y; Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas.
  • Atolagbe OT; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Rao X; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Zhao Y; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Wang J; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Ehrlich LIR; Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas.
  • Sharma P; Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, Texas.
  • Salem JE; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Balko JM; Parker Institute for Cancer Immunotherapy, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Moslehi JJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Allison JP; Department of Pharmacology, APHP. Sorbonne Université, INSERM, CIC-1901, UNICO-GRECO Cardiooncology Program, Paris, France.
Cancer Discov ; 11(3): 614-625, 2021 03.
Article em En | MEDLINE | ID: mdl-33257470
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia de Alvo Molecular / Inibidores de Checkpoint Imunológico / Miocardite / Neoplasias Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia de Alvo Molecular / Inibidores de Checkpoint Imunológico / Miocardite / Neoplasias Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article