Enantioselective Three-Component Coupling of Heteroarenes, Cycloalkenes and Propargylic Acetates.
Angew Chem Int Ed Engl
; 60(9): 4491-4495, 2021 02 23.
Article
em En
| MEDLINE
| ID: mdl-33259131
ABSTRACT
Asymmetric coupling proceeds efficiently between propargylic acetates, cycloalkenes and electron-rich heteroarenes including indoles, pyrroles, activated furans and thiophenes. 2,3-Disubstituted tetrahydrofurans and pyrrolidines are produced in trans configuration and excellent enantiomeric ratios. The reaction proceeds via Wacker-type attack of nucleophilic heteroarenes on alkenes activated by allenyl PdII species.
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MEDLINE
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En
Ano de publicação:
2021
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Article