Biologically-informed neural networks guide mechanistic modeling from sparse experimental data.
PLoS Comput Biol
; 16(12): e1008462, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-33259472
ABSTRACT
Biologically-informed neural networks (BINNs), an extension of physics-informed neural networks [1], are introduced and used to discover the underlying dynamics of biological systems from sparse experimental data. In the present work, BINNs are trained in a supervised learning framework to approximate in vitro cell biology assay experiments while respecting a generalized form of the governing reaction-diffusion partial differential equation (PDE). By allowing the diffusion and reaction terms to be multilayer perceptrons (MLPs), the nonlinear forms of these terms can be learned while simultaneously converging to the solution of the governing PDE. Further, the trained MLPs are used to guide the selection of biologically interpretable mechanistic forms of the PDE terms which provides new insights into the biological and physical mechanisms that govern the dynamics of the observed system. The method is evaluated on sparse real-world data from wound healing assays with varying initial cell densities [2].
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Simulação por Computador
/
Redes Neurais de Computação
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article