Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1.
J Org Chem
; 86(1): 475-483, 2021 01 01.
Article
em En
| MEDLINE
| ID: mdl-33263391
ABSTRACT
Chaetolactam A (1), an unprecedented azaphilone derivative bearing a unique 9-oxa-7-azabicyclo[4.2.1]octan-8-onering system, together with two new compounds, 11-epi-chaetomugilide B (2) and chaetomugilide D (3) was isolated from an endophytic fungus, Chaetomium sp. g1. Notably, extensive NMR data analyses, NMR calculations with DP4 and DP4+ analyses, ECD calculations, and the RDC method were employed to establish the structure of 1. Furthermore, 2 exhibited potent apoptosis induction activity by mediating caspase-3 activation and PARP degradation at 3 µM in HL-60.
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1
Base de dados:
MEDLINE
Assunto principal:
Chaetomium
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article