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Connection between PD-L1 expression and standardized uptake value in NSCLC: an early prognostic treatment combination.
Zarogoulidis, Paul; Christakidis, Vagelis; Petridis, Dimitris; Sapalidis, Konstantinos; Kosmidis, Chriforos; Vagionas, Anastasios; Perdikouri, Eleni-Isidora; Hohenforst-Schmidt, Wolfgang; Huang, Haidong; Petanidis, Savvas; Tsakiridis, Kosmas; Baka, Sofia; Romanidis, Konstantinos; Zaric, Bojan; Kovacevic, Tomi; Stojsic, Vladimir; Sarcev, Tatjana; Bursac, Daliborka; Kukic, Biljana; Boukovinas, Ioannis; Tolis, Christos; Sardeli, Chrysanthi.
Afiliação
  • Zarogoulidis P; 3rd Department of Surgery, ``AHEPA`` University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece.
  • Christakidis V; Oncology Department, General Hospital of Serres, Serres, Greece.
  • Petridis D; Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece.
  • Sapalidis K; 3rd Department of Surgery, ``AHEPA`` University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece.
  • Kosmidis C; 3rd Department of Surgery, ``AHEPA`` University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece.
  • Vagionas A; Oncology Department, (NHS), General Hospital of Kavala, Kavala, Greece.
  • Perdikouri EI; Oncology Department, General Hospital of Volos, Volos, Greece.
  • Hohenforst-Schmidt W; Sana Clinic Group Franken, Department of Cardiology/Pulmonology/Intensive Care/Nephrology, "Hof" Clinics, University of Erlangen, Hof, Germany.
  • Huang H; Department of Respiratory & Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, P. R. China.
  • Petanidis S; Department of Pulmonology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
  • Tsakiridis K; Thoracic Surgery Department, ``Interbalkan`` European Medical Center, Thessaloniki, Greece.
  • Baka S; Oncology Department, Interbalkan European Medical Center, Thessaloniki, Greece.
  • Romanidis K; Second Department of Surgery, General University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
  • Zaric B; Faculty of Medicine, University of Novi Sad, Institute for Pulmonary Diseases of Vojvodina, Novi Sad, Serbia.
  • Kovacevic T; Faculty of Medicine, University of Novi Sad, Institute for Pulmonary Diseases of Vojvodina, Novi Sad, Serbia.
  • Stojsic V; Faculty of Medicine, University of Novi Sad, Institute for Pulmonary Diseases of Vojvodina, Novi Sad, Serbia.
  • Sarcev T; Faculty of Medicine, University of Novi Sad, Institute for Pulmonary Diseases of Vojvodina, Novi Sad, Serbia.
  • Bursac D; Faculty of Medicine, University of Novi Sad, Institute for Pulmonary Diseases of Vojvodina, Novi Sad, Serbia.
  • Kukic B; Faculty of Medicine, University of Novi Sad, Institute for Pulmonary Diseases of Vojvodina, Novi Sad, Serbia.
  • Boukovinas I; Oncology Department, ``Bioclinic`` Private Hospital, Thessaloniki, Greece.
  • Tolis C; Oncology Department, ``Bioclinic`` Private Hospital, Thessaloniki, Greece.
  • Sardeli C; Department of Pharmacology & Clinical Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Expert Rev Respir Med ; 15(5): 675-679, 2021 05.
Article em En | MEDLINE | ID: mdl-33275458
ABSTRACT

Objectives:

Lung cancer is still diagnosed at advanced stage and early treatment initiation is needed. Therefore, we need biomarkers or clusters of information that can provide early treatment prognosis.

Methods:

Biopsies were acquired from 471 patients-lung masses with CT-guided biopsy, convex probe transthorasic biopsy, and EBUS-TBNA convex probe with 18 G needles and 19 G needles.

Results:

Standardized uptake value (SUV) measurement is associated with female, smoking status, hepatic metastasis, adenocarcinoma and programmed death-ligand 1 (PD-L1). In specific we expect that SUV ≥ 7 is associated with PD-L1 ≥ 50.

Conclusions:

Lung masses indifferent of size that have SUV ≥ 7 will also have PD-L1 expression ≥ 50. Also, it is likely that these patients will be female with intense smoking habit and hepar or multiple metastasis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article