Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice.
Brain Plast
; 5(2): 147-159, 2020 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-33282678
ABSTRACT
BACKGROUND:
Despite considerable research on exercise-induced neuroplasticity in the brain, a major ongoing challenge in translating findings from animal studies to humans is that clinical and preclinical settings employ very different techniques.OBJECTIVE:
Here we aim to bridge this divide by using diffusion tensor imaging MRI (DTI), an advanced imaging technique commonly applied in human studies, in a longitudinal exercise study with mice.METHODS:
Wild-type mice were exercised using voluntary free-wheel running, and MRI scans were at baseline and after four weeks and nine weeks of running.RESULTS:
Both hippocampal volume and fractional anisotropy, a surrogate for microstructural directionality, significantly increased with exercise. In addition, exercise levels correlated with effect size. Histological analysis showed more PDGFRα+ oligodendrocyte precursor cells in the corpus callosum of running mice.CONCLUSIONS:
These results provide compelling in vivo support for the concept that similar adaptive changes occur in the brains of mice and humans in response to exercise.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article