Screening for infantile hepatic hemangioma in patients with cutaneous infantile hemangioma: A multicenter prospective study.
J Am Acad Dermatol
; 84(5): 1378-1384, 2021 May.
Article
em En
| MEDLINE
| ID: mdl-33285272
ABSTRACT
BACKGROUND:
Abdominal ultrasonography has been proposed to screen for infantile hepatic hemangioma (IHH) in patients with multiple cutaneous infantile hemangiomas (IHs).OBJECTIVES:
The aim of this study was to establish the optimal cutoff point for the number of cutaneous IHs needed to screen for IHH.METHODS:
We performed a prospective, multicenter study to screen for IHH in patients younger than 9 months who had multiple cutaneous IHs (n ≥ 3) on ultrasonography. For comparison, a group of patients with 1 or 2 focal cutaneous IHs was also recruited.RESULTS:
In total, 676 patients with at least 3 cutaneous IHs and 980 patients with 1 or 2 focal cutaneous IHs were enrolled. Thirty-one patients were found to have IHH. A higher number of cutaneous IHs was associated with an increased risk of IHH (R = 0.973; P < .001). Receiver operating characteristic curve analysis showed that 5 cutaneous IHs was the optimal cutoff point to screen for IHH, with an area under the curve of 0.872 (P < .001; 95% confidence interval, 0.789-0.955).LIMITATIONS:
This was an uncontrolled study.CONCLUSIONS:
Screening for IHH is recommended in patients younger than 9 months who present with 5 or more cutaneous IHs.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Hemangioma
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Fígado
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Neoplasias Hepáticas
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article