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Extracellular vesicles derived from fibroblasts promote wound healing by optimizing fibroblast and endothelial cellular functions.
Oh, Eun Jung; Gangadaran, Prakash; Rajendran, Ramya Lakshmi; Kim, Hyun Mi; Oh, Ji Min; Choi, Kang Young; Chung, Ho Yun; Ahn, Byeong-Cheol.
Afiliação
  • Oh EJ; Department of Plastic and Reconstructive Surgery, CMRI, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
  • Gangadaran P; Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
  • Rajendran RL; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
  • Kim HM; Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
  • Oh JM; Department of Plastic and Reconstructive Surgery, CMRI, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
  • Choi KY; Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
  • Chung HY; Department of Plastic and Reconstructive Surgery, CMRI, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
  • Ahn BC; Department of Plastic and Reconstructive Surgery, CMRI, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
Stem Cells ; 39(3): 266-279, 2021 03.
Article em En | MEDLINE | ID: mdl-33289943
ABSTRACT
Extracellular vesicles (EVs) have been exhibited as promising candidates for delivering endogenous therapeutic cargos for regenerative therapies. Fibroblasts could be candidate source cells for EVs, to investigate their therapeutic effects in wound healing. Here we demonstrated the isolation and characterization of fibroblast-derived (L929 cell line) EVs (L929-EVs). Furthermore, L929-EVs treatment showed pro-wound healing effects in vitro by enhancing proliferation, migration, and scarless wound healing related genes in fibroblast cells. L929-EVs treatment also enhanced the migration and tube formation of endothelial cells. The combination of L929-EVs with fibrin glue accelerated wound healing in the mouse skin wound model by enhancing collagen formation, collagen maturation, and blood vessels in the wounded skin. The role of fibroblast-derived EVs in wound healing could be an important phenomenon, and fibroblast-derived EVs could be harnessed for wound healing therapies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cicatrização / Células Endoteliais / Fibroblastos / Vesículas Extracelulares Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cicatrização / Células Endoteliais / Fibroblastos / Vesículas Extracelulares Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article