Application of the PET ligand [<sup>11</sup>C]ORM-13070 to examine receptor occupancy by the &#945;<sub>2C</sub>-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain.

Shahid, Mohammed; Rinne, Juha O; Scheinin, Mika; Virta, Jere; Marjamäki, Päivi; Solin, Olof; Arponen, Eveliina; Sallinen, Jukka; Kuokkanen, Katja; Rouru, Juha

Application of the PET ligand [¹¹C]ORM-13070 to examine receptor occupancy by the α_2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain.

Shahid, Mohammed; Rinne, Juha O; Scheinin, Mika; Virta, Jere; Marjamäki, Päivi; Solin, Olof; Arponen, Eveliina; Sallinen, Jukka; Kuokkanen, Katja; Rouru, Juha.

Afiliação

Shahid M; Orion Corporation, Orion Pharma, Research and Development, Tengströminkatu 8, 20380, Espoo, Finland.
Rinne JO; Orion Corporation, Orion Pharma, Research and Development, Nottingham, UK.
Scheinin M; Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
Virta J; Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland.
Marjamäki P; CRST, Turku, Finland.
Solin O; Institute of Biomedicine, University of Turku, Turku, Finland.
Arponen E; Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland.
Sallinen J; Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
Kuokkanen K; Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland.
Rouru J; Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.