Adherence to a healthy lifestyle and multiple sclerosis: a case-control study from the UK Biobank.
Nutr Neurosci
; 25(6): 1231-1239, 2022 Jun.
Article
em En
| MEDLINE
| ID: mdl-33297884
ABSTRACT
BACKGROUND:
Multiple sclerosis (MS) is a common and disabling condition. The importance of healthy lifestyle for this disease is poorly explored.OBJECTIVE:
To test whether adherence to healthier lifestyle patterns is associated with a lower presence of multiple sclerosis (MS).METHODS:
By using a case-control design, we investigated the combined association of four healthy lifestyle-related factors (no current smoking, healthy diet, exercising regularly, body mass index <30â kg/m2) and the prevalence of MS. A logistic regression analysis, adjusted for potential confounders, was used and data reported as odds ratios (ORs) with their 95% confidence intervals (CIs).RESULTS:
728 participants with MS were matched with healthy controls (n = 2,912) using a propensity score approach. In a multivariable analysis, compared to those who scored low in the composite lifestyle score (0-1 healthy lifestyle factors), people who adopted all four low risk lifestyle factors showed a 71% lower odds of having MS (OR = 0.29; 95% CI 0.15-0.56). Moreover, there was a strong linear trend, suggesting that the higher number of healthy lifestyle behaviors was associated with lower odds of having MS.CONCLUSION:
Following a healthy lifestyle is associated with a lower prevalence of MS. This association should be explored further in cohort studies.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esclerose Múltipla
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article