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Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production.
Cvetko, Filip; Caldwell, Stuart T; Higgins, Maureen; Suzuki, Takafumi; Yamamoto, Masayuki; Prag, Hiran A; Hartley, Richard C; Dinkova-Kostova, Albena T; Murphy, Michael P.
Afiliação
  • Cvetko F; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
  • Caldwell ST; School of Chemistry, University of Glasgow, Glasgow, UK.
  • Higgins M; Division of Cellular Medicine, School of Medicine, Jacqui Wood Cancer Centre, University of Dundee, Dundee, Scotland, UK.
  • Suzuki T; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Yamamoto M; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
  • Hartley RC; School of Chemistry, University of Glasgow, Glasgow, UK.
  • Dinkova-Kostova AT; Division of Cellular Medicine, School of Medicine, Jacqui Wood Cancer Centre, University of Dundee, Dundee, Scotland, UK; Department of Pharmacology and Molecular Sciences and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address: mpm@mrc-mbu.cam.ac.uk.
J Biol Chem ; 296: 100169, 2021.
Article em En | MEDLINE | ID: mdl-33298526
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Sulfidrila / Superóxidos / Fator 2 Relacionado a NF-E2 / Proteína 1 Associada a ECH Semelhante a Kelch / Mitocôndrias Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Sulfidrila / Superóxidos / Fator 2 Relacionado a NF-E2 / Proteína 1 Associada a ECH Semelhante a Kelch / Mitocôndrias Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article