Gene dosage manipulation alleviates manifestations of hereditary <i>PAX6</i> haploinsufficiency in mice.

Rabiee, Behnam; Anwar, Khandaker N; Shen, Xiang; Putra, Ilham; Liu, Mingna; Jung, Rebecca; Afsharkhamseh, Neda; Rosenblatt, Mark I; Fishman, Gerald A; Liu, Xiaorong; Ghassemi, Mahmood; Djalilian, Ali R

Gene dosage manipulation alleviates manifestations of hereditary PAX6 haploinsufficiency in mice.

Rabiee, Behnam; Anwar, Khandaker N; Shen, Xiang; Putra, Ilham; Liu, Mingna; Jung, Rebecca; Afsharkhamseh, Neda; Rosenblatt, Mark I; Fishman, Gerald A; Liu, Xiaorong; Ghassemi, Mahmood; Djalilian, Ali R.

Afiliação

Rabiee B; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Anwar KN; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Shen X; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Putra I; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Liu M; Departments of Biology and Psychology, University of Virginia, Charlottesville, VA 22903, USA.
Jung R; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Afsharkhamseh N; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Rosenblatt MI; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Fishman GA; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Liu X; Pangere Center for Inherited Retinal Diseases, The Chicago Lighthouse, Chicago, IL 60608, USA.
Ghassemi M; Departments of Biology and Psychology, University of Virginia, Charlottesville, VA 22903, USA.
Djalilian AR; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.

Sci Transl Med ; 12(573)2020 12 09.

Article em En | MEDLINE | ID: mdl-33298563

Assuntos

Haploinsuficiência; Fatores de Transcrição Box Pareados; Animais; Proteínas do Olho/genética; Dosagem de Genes; Proteínas de Homeodomínio/genética; Camundongos; Fator de Transcrição PAX6/genética; Fatores de Transcrição Box Pareados/genética; Proteínas Repressoras/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição Box Pareados / Haploinsuficiência Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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