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TGFß-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts.
Grauel, Angelo L; Nguyen, Beverly; Ruddy, David; Laszewski, Tyler; Schwartz, Stephanie; Chang, Jonathan; Chen, Julie; Piquet, Michelle; Pelletier, Marc; Yan, Zheng; Kirkpatrick, Nathaniel D; Wu, Jincheng; deWeck, Antoine; Riester, Markus; Hims, Matt; Geyer, Felipe Correa; Wagner, Joel; MacIsaac, Kenzie; Deeds, James; Diwanji, Rohan; Jayaraman, Pushpa; Yu, Yenyen; Simmons, Quincey; Weng, Shaobu; Raza, Alina; Minie, Brian; Dostalek, Mirek; Chikkegowda, Pavitra; Ruda, Vera; Iartchouk, Oleg; Chen, Naiyan; Thierry, Raphael; Zhou, Joseph; Pruteanu-Malinici, Iulian; Fabre, Claire; Engelman, Jeffrey A; Dranoff, Glenn; Cremasco, Viviana.
Afiliação
  • Grauel AL; Immuno-Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Nguyen B; Immuno-Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Ruddy D; Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Laszewski T; Immuno-Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Schwartz S; Immuno-Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Chang J; Immuno-Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Chen J; Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Piquet M; Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Pelletier M; Oncology Translational Research, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Yan Z; Oncology Translational Research, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Kirkpatrick ND; Biotherapeutic and Analytical Technologies, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Wu J; Oncology Data Science, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • deWeck A; Oncology Data Science, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Riester M; Oncology Data Science, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Hims M; Oncology Translational Research, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Geyer FC; Oncology Translational Research, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Wagner J; Oncology Data Science, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • MacIsaac K; Oncology Data Science, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Deeds J; Oncology Translational Research, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Diwanji R; Immuno-Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Jayaraman P; Immuno-Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Yu Y; Oncology Translational Research, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Simmons Q; Oncology Data Science, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Weng S; Oncology Translational Research, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Raza A; Oncology Translational Research, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Minie B; Oncology Data Science, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Dostalek M; PKS Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Chikkegowda P; Immuno-Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Ruda V; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Iartchouk O; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Chen N; Oncology Data Science, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Thierry R; Biotherapeutic and Analytical Technologies, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Zhou J; Immuno-Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Pruteanu-Malinici I; Immuno-Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Fabre C; Translational Clinical Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Engelman JA; Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Dranoff G; Immuno-Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Cremasco V; Immuno-Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA, 02139, USA. viviana.cremasco@novartis.com.
Nat Commun ; 11(1): 6315, 2020 12 09.
Article em En | MEDLINE | ID: mdl-33298926
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Fator de Crescimento Transformador beta / Interferon beta / Fibroblastos Associados a Câncer Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Fator de Crescimento Transformador beta / Interferon beta / Fibroblastos Associados a Câncer Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article