Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis.
RSC Chem Biol
; 1(1): 8-12, 2020 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-33305272
ABSTRACT
Using a covalent chemical probe and X-ray crystallography coupled to nuclear magnetic resonance data, we elucidated the dynamic molecular basis of protein recognition between the carrier protein and adenylation domain in pyoluteorin biosynthesis. These findings reveal a unique binding mode, which contrasts previously solved carrier protein and partner protein interfaces.
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MEDLINE
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En
Ano de publicação:
2020
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Article