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Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer's disease.
Toublet, François-Xavier; Lalut, Julien; Hatat, Bérénice; Lecoutey, Cédric; Davis, Audrey; Since, Marc; Corvaisier, Sophie; Freret, Thomas; Sopková-de Oliveira Santos, Jana; Claeysen, Sylvie; Boulouard, Michel; Dallemagne, Patrick; Rochais, Christophe.
Afiliação
  • Toublet FX; Normandie Univ, Unicaen, CERMN, 14000 Caen, France.
  • Lalut J; Normandie Univ, Unicaen, CERMN, 14000 Caen, France.
  • Hatat B; Normandie Univ, Unicaen, CERMN, 14000 Caen, France; IGF, Univ. Montpellier, CNRS, INSERM Montpellier, France.
  • Lecoutey C; Normandie Univ, Unicaen, CERMN, 14000 Caen, France.
  • Davis A; Normandie Univ, Unicaen, CERMN, 14000 Caen, France.
  • Since M; Normandie Univ, Unicaen, CERMN, 14000 Caen, France.
  • Corvaisier S; Normandie Univ, Unicaen, CERMN, 14000 Caen, France.
  • Freret T; Normandie Univ, Unicaen, INSERM, Comete, GIP CYCERON, 14000 Caen, France.
  • Sopková-de Oliveira Santos J; Normandie Univ, Unicaen, CERMN, 14000 Caen, France.
  • Claeysen S; IGF, Univ. Montpellier, CNRS, INSERM Montpellier, France.
  • Boulouard M; Normandie Univ, Unicaen, INSERM, Comete, GIP CYCERON, 14000 Caen, France.
  • Dallemagne P; Normandie Univ, Unicaen, CERMN, 14000 Caen, France.
  • Rochais C; Normandie Univ, Unicaen, CERMN, 14000 Caen, France. Electronic address: christophe.rochais@unicaen.fr.
Eur J Med Chem ; 210: 113059, 2021 Jan 15.
Article em En | MEDLINE | ID: mdl-33310288
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Butirilcolinesterase / Pró-Fármacos / Desenho de Fármacos / Inibidores da Colinesterase / Receptores de Serotonina / Doença de Alzheimer Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Butirilcolinesterase / Pró-Fármacos / Desenho de Fármacos / Inibidores da Colinesterase / Receptores de Serotonina / Doença de Alzheimer Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article