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Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 associated with acquired immunodeficiency syndrome: A case report.
Peçanha, Paulo Mendes; Bahiense, Isabela Cruz; Kruschewsky, Wdson Luis Lima; Biasutti, Cláudia; Júnior, Carlos Urbano Gonçalves Ferreira; Pinheiro, Breno Gonçalves; Maifrede, Simone Bravim; Camargo, Zoilo Pires de; Rodrigues, Anderson Messias; Grão-Velloso, Tânia Regina; Falqueto, Aloísio; Gonçalves, Sarah Santos.
Afiliação
  • Peçanha PM; Universidade Federal do Espírito Santo-UFES, Brazil.
  • Bahiense IC; Universidade Federal do Espírito Santo-UFES, Brazil.
  • Kruschewsky WLL; Universidade Federal do Espírito Santo-UFES, Brazil.
  • Biasutti C; Hospital Universitário Cassiano Antônio Moraes-UFES, Brazil.
  • Júnior CUGF; Hospital Universitário Cassiano Antônio Moraes-UFES, Brazil.
  • Pinheiro BG; Universidade Federal de São Paulo-UNIFESP, Brazil.
  • Maifrede SB; Universidade Federal do Espírito Santo-UFES, Brazil.
  • Camargo ZP; Universidade Federal de São Paulo-UNIFESP, Brazil.
  • Rodrigues AM; Universidade Federal de São Paulo-UNIFESP, Brazil.
  • Grão-Velloso TR; Universidade Federal do Espírito Santo-UFES, Brazil.
  • Falqueto A; Universidade Federal do Espírito Santo-UFES, Brazil.
  • Gonçalves SS; Universidade Federal do Espírito Santo-UFES, Brazil. Electronic address: sarah.tavares@ufes.br.
Rev Iberoam Micol ; 38(1): 5-8, 2021.
Article em En | MEDLINE | ID: mdl-33317932
BACKGROUND: Paracoccidioidomycosis (PCM) is an endemic disease in Latin America. In immunocompetent hosts, PCM occurs in two main clinical forms: acute and chronic. However, in HIV-infected patients PCM may show up simultaneous manifestations of acute and chronic forms. CASE REPORT: We present the case of a patient diagnosed with HIV who had disseminated skin lesions and generalized lymphadenopathy, as well as respiratory and central nervous system involvement. The PCM diagnosis was confirmed by direct KOH examination, double immunodiffusion and the isolation of the fungus in samples of an abscess in the subcostal region. The isolate was identified as Paracoccidioides brasiliensis S1 by species-specific PCR using primers for protein-coding gene GP43 (exon 2) followed by PCR-RFLP of the alpha-tubulin gene. CONCLUSIONS: There are few data in literature reporting species-specific molecular identification of Paracoccidioides in HIV/PCM patients. Therefore, this case report may contribute to improve the knowledge about this severe disease, its causative cryptic species, and its consequences to patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Paracoccidioides / Paracoccidioidomicose / Síndrome da Imunodeficiência Adquirida Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Paracoccidioides / Paracoccidioidomicose / Síndrome da Imunodeficiência Adquirida Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2021 Tipo de documento: Article