Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report.
Front Immunol
; 11: 603428, 2020.
Article
em En
| MEDLINE
| ID: mdl-33329599
ABSTRACT
In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Wiskott-Aldrich
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Terapia Genética
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Anticorpos Neutralizantes
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SARS-CoV-2
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COVID-19
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Anticorpos Antivirais
Limite:
Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article