Could Altered Evoked Pain Responsiveness Be a Phenotypic Biomarker for Alzheimer's Disease Risk? A Cross-Sectional Analysis of Cognitively Healthy Individuals.
J Alzheimers Dis
; 79(3): 1227-1233, 2021.
Article
em En
| MEDLINE
| ID: mdl-33337380
ABSTRACT
BACKGROUND:
This study evaluated whether the apolipoprotein É4 (APOE4) allele, a genetic marker associated with increased risk of developing late-onset Alzheimer's disease (AD), was associated with differences in evoked pain responsiveness in cognitively healthy subjects.OBJECTIVE:
The aim was to determine whether individuals at increased risk of late-onset AD based on APOE allele genotype differ phenotypically in their response to experimentally-induced painful stimuli compared to those who do not have at least one copy of the É4 allele.METHODS:
Forty-nine cognitively healthy subjects aged 30-89 years old with the APOE4 allele (nâ=â12) and without (nâ=â37) were assessed for group differences in pain thresholds and affective (unpleasantness) responses to experimentally-induced thermal pain stimuli.RESULTS:
Statistically significant main effects of APOE4 status were observed for both the temperature at which three different pain intensity percepts were reached (pâ=â0.040) and the level of unpleasantness associated with each (pâ=â0.014). APOE4 positive participants displayed lower overall pain sensitivity than those who were APOE4 negative and also greater overall levels of pain unpleasantness regardless of intensity level.CONCLUSION:
Cognitively healthy APOE4 carriers at increased risk of late-onset AD demonstrated reduced thermal pain sensitivity but greater unpleasantness to thermal pain stimuli relative to individuals at lower risk of late-onset AD. These results suggest that altered evoked pain perception could potentially be used as a phenotypic biomarker of late-onset AD risk prior to disease onset. Additional studies of this issue may be warranted.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Percepção da Dor
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Doença de Alzheimer
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article