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Recovery of Theta Frequency Oscillations in Rats Following Lateral Fluid Percussion Corresponds With a Mild Cognitive Phenotype.
Ondek, Katelynn; Pevzner, Aleksandr; Tercovich, Kayleen; Schedlbauer, Amber M; Izadi, Ali; Ekstrom, Arne D; Cowen, Stephen L; Shahlaie, Kiarash; Gurkoff, Gene G.
Afiliação
  • Ondek K; Department of Neurological Surgery, University of California, Davis, Davis, CA, United States.
  • Pevzner A; Center for Neuroscience, University of California, Davis, Davis, CA, United States.
  • Tercovich K; Department of Neurological Surgery, University of California, Davis, Davis, CA, United States.
  • Schedlbauer AM; Department of Neurological Surgery, University of California, Davis, Davis, CA, United States.
  • Izadi A; Center for Neuroscience, University of California, Davis, Davis, CA, United States.
  • Ekstrom AD; Department of Neurological Surgery, University of California, Davis, Davis, CA, United States.
  • Cowen SL; Center for Neuroscience, University of California, Davis, Davis, CA, United States.
  • Shahlaie K; Department of Neurological Surgery, University of California, Davis, Davis, CA, United States.
  • Gurkoff GG; Center for Neuroscience, University of California, Davis, Davis, CA, United States.
Front Neurol ; 11: 600171, 2020.
Article em En | MEDLINE | ID: mdl-33343499
ABSTRACT
Whether from a fall, sports concussion, or even combat injury, there is a critical need to identify when an individual is able to return to play or work following traumatic brain injury (TBI). Electroencephalogram (EEG) and local field potentials (LFP) represent potential tools to monitor circuit-level abnormalities related to learning and memory specifically, theta oscillations can be readily observed and play a critical role in cognition. Following moderate traumatic brain injury in the rat, lasting changes in theta oscillations coincide with deficits in spatial learning. We hypothesized, therefore, that theta oscillations can be used as an objective biomarker of recovery, with a return of oscillatory activity corresponding with improved spatial learning. In the current study, LFP were recorded from dorsal hippocampus and anterior cingulate in awake, behaving adult Sprague Dawley rats in both a novel environment on post-injury days 3 and 7, and Barnes maze spatial navigation on post-injury days 8-11. Theta oscillations, as measured by power, theta-delta ratio, peak theta frequency, and phase coherence, were significantly altered on day 3, but had largely recovered by day 7 post-injury. Injured rats had a mild behavioral phenotype and were not different from shams on the Barnes maze, as measured by escape latency. Injured rats did use suboptimal search strategies. Combined with our previous findings that demonstrated a correlation between persistent alterations in theta oscillations and spatial learning deficits, these new data suggest that neural oscillations, and particularly theta oscillations, have potential as a biomarker to monitor recovery of brain function following TBI. Specifically, we now demonstrate that oscillations are depressed following injury, but as oscillations recover, so does behavior.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article