Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-<i>d</i>]pyridazinone-Based 1,3,4-Oxadiazole as New Class of Selective COX-2 Inhibitors.

Szczukowski, Lukasz; Krzyzak, Edward; Zborowska, Adrianna; Zajac, Patrycja; Potyrak, Katarzyna; Peregrym, Krzysztof; Wiatrak, Benita; Marciniak, Aleksandra; Swiatek, Piotr

Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-d]pyridazinone-Based 1,3,4-Oxadiazole as New Class of Selective COX-2 Inhibitors.

Szczukowski, Lukasz; Krzyzak, Edward; Zborowska, Adrianna; Zajac, Patrycja; Potyrak, Katarzyna; Peregrym, Krzysztof; Wiatrak, Benita; Marciniak, Aleksandra; Swiatek, Piotr.

Afiliação

Szczukowski L; Department of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Krzyzak E; Department of Inorganic Chemistry, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.
Zborowska A; Student Scientific Club of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Zajac P; Student Scientific Club of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Potyrak K; Student Scientific Club of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Peregrym K; Student Scientific Club of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Wiatrak B; Department of Basic Medical Sciences, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Marciniak A; Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.
Swiatek P; Department of Inorganic Chemistry, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.

Int J Mol Sci ; 21(24)2020 Dec 17.

Article em En | MEDLINE | ID: mdl-33348757

Assuntos

Antioxidantes/química; Antioxidantes/farmacologia; Inibidores de Ciclo-Oxigenase 2/química; Inibidores de Ciclo-Oxigenase 2/farmacologia; Desenho de Fármacos; Bases de Mannich/química; Oxidiazóis/química; Piridazinas/farmacologia; Pirróis/farmacologia; Antioxidantes/síntese química; Domínio Catalítico; Linhagem Celular; Sobrevivência Celular/efeitos dos fármacos; Dicroísmo Circular; Ciclo-Oxigenase 2/metabolismo; Inibidores de Ciclo-Oxigenase 2/síntese química; Feminino; Fibroblastos/metabolismo; Humanos; Concentração Inibidora 50; Pessoa de Meia-Idade; Simulação de Acoplamento Molecular; Estrutura Molecular; Piridazinas/síntese química; Piridazinas/química; Pirróis/síntese química; Pirróis/química; Soroalbumina Bovina/química; Relação Estrutura-Atividade

Palavras-chave

1,3,4-oxadiazole; DNA protection; anti-inflammatory activity; anti-oxidant agents; double pharmacophore approach; molecular docking; selective COX-2 inhibitors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxidiazóis / Piridazinas / Pirróis / Desenho de Fármacos / Inibidores de Ciclo-Oxigenase 2 / Bases de Mannich / Antioxidantes Tipo de estudo: Prognostic_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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