Epipyrone A, a Broad-Spectrum Antifungal Compound Produced by Epicoccum nigrum ICMP 19927.
Molecules
; 25(24)2020 Dec 18.
Article
em En
| MEDLINE
| ID: mdl-33352899
ABSTRACT
We have isolated a filamentous fungus that actively secretes a pigmented exudate when growing on agar plates. The fungus was identified as being a strain of Epicoccum nigrum. The fungal exudate presented strong antifungal activity against both yeasts and filamentous fungi, and inhibited the germination of fungal spores. The chemical characterization of the exudate showed that the pigmented molecule presenting antifungal activity is the disalt of epipyrone A-a water-soluble polyene metabolite with a molecular mass of 612.29 and maximal UV-Vis absorbance at 428 nm. This antifungal compound showed excellent stability to different temperatures and neutral to alkaline pH.
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Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Leveduras
/
Antifúngicos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article