Your browser doesn't support javascript.
loading
Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response.
Desai, Radha; East, Daniel A; Hardy, Liana; Faccenda, Danilo; Rigon, Manuel; Crosby, James; Alvarez, María Soledad; Singh, Aarti; Mainenti, Marta; Hussey, Laura Kuhlman; Bentham, Robert; Szabadkai, Gyorgy; Zappulli, Valentina; Dhoot, Gurtej K; Romano, Lisa E; Xia, Dong; Coppens, Isabelle; Hamacher-Brady, Anne; Chapple, J Paul; Abeti, Rosella; Fleck, Roland A; Vizcay-Barrena, Gema; Smith, Kenneth; Campanella, Michelangelo.
Afiliação
  • Desai R; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
  • East DA; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
  • Hardy L; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
  • Faccenda D; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
  • Rigon M; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
  • Crosby J; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
  • Alvarez MS; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
  • Singh A; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
  • Mainenti M; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
  • Hussey LK; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
  • Bentham R; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research (CfMR), University College London, Gower Street, London WC1E 6BT, UK.
  • Szabadkai G; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research (CfMR), University College London, Gower Street, London WC1E 6BT, UK.
  • Zappulli V; Department of Biomedical Science, University of Padua, Via Ugo Bassi, 35131 Padua, Italy.
  • Dhoot GK; Francis Crick Institute, Midland Road, London NW1 AT, UK.
  • Romano LE; Department of Comparative Biomedicine and Food Sciences, University of Padua, Viale dell'Universita' 16, 35020 Legnaro (PD), Italy.
  • Xia D; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
  • Coppens I; William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK.
  • Hamacher-Brady A; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
  • Chapple JP; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Baltimore, Baltimore, MD 21205, USA.
  • Abeti R; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Baltimore, Baltimore, MD 21205, USA.
  • Fleck RA; William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK.
  • Vizcay-Barrena G; Ataxia Centre, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
  • Smith K; Centre for Ultrastructural Imaging, King's College London, London SE1 1UL, UK.
  • Campanella M; Centre for Ultrastructural Imaging, King's College London, London SE1 1UL, UK.
Sci Adv ; 6(51)2020 12.
Article em En | MEDLINE | ID: mdl-33355129
ABSTRACT
Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus. This process is known as mitochondrial retrograde response (MRR) and is induced by mitochondrial dysfunction. MRR results in the nuclear stabilization of prosurvival transcription factors such as the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Here, we demonstrate that MRR is facilitated by contact sites between mitochondria and the nucleus. The translocator protein (TSPO) by preventing the mitophagy-mediated segregation o mitochonria is required for this interaction. The complex formed by TSPO with the protein kinase A (PKA), via the A-kinase anchoring protein acyl-CoA binding domain containing 3 (ACBD3), established the tethering. The latter allows for cholesterol redistribution of cholesterol in the nucleus to sustain the prosurvival response by blocking NF-κB deacetylation. This work proposes a previously unidentified paradigm in MRR the formation of contact sites between mitochondria and nucleus to aid communication.
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article