Lipid-protein forces predict conformational changes in a mechanosensitive channel.
Eur Biophys J
; 50(2): 181-186, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-33355710
ABSTRACT
The mechanosensitive TREK-2 potassium channel, a member of the K2P family, has essential physiological roles and is, therefore, a pharmaceutical target. A combination of experimental and computational studies have established that of the two known conformations, "up" and "down", membrane tension directly favors the "up" state, which displays a higher conductance. However, these studies did not reveal the exact mechanism by which the membrane affects the channel conformation. In this work, we show that changes in protein-lipid interaction patterns suffice in predicting this conformational change, and pinpoint potentially important residues involved in this phenomenon.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ativação do Canal Iônico
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Mecanotransdução Celular
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Metabolismo dos Lipídeos
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Proteínas de Membrana
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article