Phenylbutyrate, a branched-chain amino acid keto dehydrogenase activator, promotes branched-chain amino acid metabolism and induces muscle catabolism in C2C12 cells.

Crossland, Hannah; Smith, Kenneth; Idris, Iskandar; Phillips, Bethan E; Atherton, Philip J; Wilkinson, Daniel J

Crossland, Hannah; Smith, Kenneth; Idris, Iskandar; Phillips, Bethan E; Atherton, Philip J; Wilkinson, Daniel J.

Afiliação

Crossland H; MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, UK.
Smith K; MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, UK.
Idris I; MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, UK.
Phillips BE; MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, UK.
Atherton PJ; MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, UK.
Wilkinson DJ; MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, UK.

Exp Physiol ; 106(3): 585-592, 2021 03.

Article em En | MEDLINE | ID: mdl-33369803

Assuntos

Músculo Esquelético; Fenilbutiratos; Aminoácidos de Cadeia Ramificada/metabolismo; Animais; Linhagem Celular; Camundongos; Músculo Esquelético/metabolismo; Oxirredutases/metabolismo; Fenilbutiratos/metabolismo; Fenilbutiratos/farmacologia

Palavras-chave

branched-chain amino acids; mTOR; muscle protein synthesis; phenylbutyrate; skeletal muscle

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenilbutiratos / Músculo Esquelético Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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