Uninephrectomy and class II PI3K-C2ß inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice.

Alliouachene, Samira; Kieswich, Julius E; Bilanges, Benoit; McCafferty, Kieran; Thiemermann, Christoph; Vanhaesebroeck, Bart; Yaqoob, Muhammad M

Alliouachene, Samira; Kieswich, Julius E; Bilanges, Benoit; McCafferty, Kieran; Thiemermann, Christoph; Vanhaesebroeck, Bart; Yaqoob, Muhammad M.

Afiliação

Alliouachene S; Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Kieswich JE; Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Bilanges B; UCL Cancer Institute, University College London, London, UK.
McCafferty K; Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Thiemermann C; Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Vanhaesebroeck B; UCL Cancer Institute, University College London, London, UK.
Yaqoob MM; Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.

Am J Transplant ; 21(8): 2688-2697, 2021 08.

Article em En | MEDLINE | ID: mdl-33370494

Assuntos

Classe II de Fosfatidilinositol 3-Quinases/genética; Diabetes Mellitus Tipo 2; Fígado Gorduroso; Resistência à Insulina; Animais; Diabetes Mellitus Tipo 2/etiologia; Fígado Gorduroso/etiologia; Fígado Gorduroso/prevenção & controle; Insulina; Fígado; Camundongos; Camundongos Endogâmicos C57BL; Obesidade/etiologia

Palavras-chave

basic (laboratory) research/science; diabetes: type 2; donors and donation: donor follow-up; endocrinology/diabetology; kidney transplantation/nephrology; kidney transplantation: living donor; metabolic syndrome; signaling/signaling pathways: PI-3 kinase/Akt pathway; translational research/science

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Diabetes Mellitus Tipo 2 / Fígado Gorduroso / Classe II de Fosfatidilinositol 3-Quinases Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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