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Plasma Inflammatory Biomarkers Predict CD4+ T-cell Recovery and Viral Rebound in HIV-1 Infected Africans on Suppressive Antiretroviral Therapy.
Kroeze, Stefanie; Rossouw, Theresa M; Steel, Helen C; Wit, Ferdinand W; Kityo, Cissy M; Siwale, Margaret; Akanmu, Sulaimon; Mandaliya, Kishor; De Jager, Marleen; Ondoa, Pascale; Reiss, Peter; Rinke De Wit, Tobias F; Kootstra, Neeltje A; Hamers, Raph L.
Afiliação
  • Kroeze S; Amsterdam Institute for Global Health and Development, and Department of Global Health, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Rossouw TM; Department of Experimental Immunology, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Steel HC; Department of Immunology, University of Pretoria, Pretoria, South Africa.
  • Wit FW; Department of Immunology, University of Pretoria, Pretoria, South Africa.
  • Kityo CM; Amsterdam Institute for Global Health and Development, and Department of Global Health, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Siwale M; Stichting HIV Monitoring, Amsterdam, the Netherlands.
  • Akanmu S; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Mandaliya K; Joint Clinical Research Centre, Kampala, Uganda.
  • De Jager M; Lusaka Trust Hospital, Lusaka, Zambia.
  • Ondoa P; Department of Haematology and Blood Transfusion, College of Medicine of the University of Lagos and the Lagos University Teaching Hospital, Lagos, Nigeria.
  • Reiss P; Coast Province General Hospital, Mombasa, Kenya.
  • Rinke De Wit TF; Muelmed Hospital, Pretoria, South Africa.
  • Kootstra NA; Amsterdam Institute for Global Health and Development, and Department of Global Health, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Hamers RL; African Society of Laboratory Medicine, Addis Ababa, Ethiopia.
J Infect Dis ; 224(4): 673-678, 2021 08 16.
Article em En | MEDLINE | ID: mdl-33373447
This multicountry prospective study investigated whether persistent systemic inflammation, measured by 8 plasma biomarkers, in HIV-1-infected Africans during suppressive antiretroviral therapy (ART) (viral load <50 copies/mL), was associated with CD4+ T-cell recovery and viral rebound (>1000 copies/mL) during long-term treatment. On-ART sCD14 and C-reactive protein concentrations were inversely associated with subsequent CD4+ T-cell counts. Risk of viral rebound was increased for participants with higher on-ART CXCL10 concentrations and reduced for those with a greater sCD163 decline during the first year of ART. Persistent systemic inflammation predicted CD4+ T-cell recovery and viral rebound, warranting further mechanistic research in relation to clinical outcomes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Infecções por HIV / Soropositividade para HIV / Fármacos Anti-HIV Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Infecções por HIV / Soropositividade para HIV / Fármacos Anti-HIV Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article