[FOXO3a signaling pathway in prostate cancer: Progress in studies].
Zhonghua Nan Ke Xue
; 26(8): 745-750, 2020 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-33377739
ABSTRACT
FOXO3a is an important member of the FOXO subfamily of Forkhead transcription factors, which plays an important role in promoting cell apoptosis, inducing cell cycle arrest, inhibiting cell proliferation and suppressing tumor metastasis through phosphorylation, ubiquitination-mediated degradation and microRNA. Studies show that upregulated expression of FOXO3a can inhibit the growth of PCa cells. This review summarizes the advances in the studies of the FOXO3a signaling pathway in PCa, aiming to provide some new ideas on the clinical diagnosis and targeted therapy of the malignancy.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Transdução de Sinais
/
Proteína Forkhead Box O3
Limite:
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2020
Tipo de documento:
Article