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Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response.
Dela Cruz Chuh, Josefa; Go, MaryAnn; Chen, Yvonne; Guo, Jun; Rafidi, Hanine; Mandikian, Danielle; Sun, Yonglian; Lin, Zhonghua; Schneider, Kellen; Zhang, Pamela; Vij, Rajesh; Sharpnack, Danielle; Chan, Pamela; de la Cruz, Cecile; Sadowsky, Jack; Seshasayee, Dhaya; Koerber, James T; Pillow, Thomas H; Phillips, Gail D; Rowntree, Rebecca K; Boswell, C Andrew; Kozak, Katherine R; Polson, Andrew G; Polakis, Paul; Yu, Shang-Fan; Dragovich, Peter S; Agard, Nicholas J.
Afiliação
  • Dela Cruz Chuh J; Departments of Biochemical and Cellular Pharmacology, Genentech Inc , South San Francisco, CA, USA.
  • Go M; Research biology, Genentech Inc , South San Francisco, CA, USA.
  • Chen Y; Antibody Engineering, Genentech Inc , South San Francisco, CA, USA.
  • Guo J; Research biology, Genentech Inc , South San Francisco, CA, USA.
  • Rafidi H; Preclinical & Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc , South San Francisco, CA, USA.
  • Mandikian D; Preclinical & Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc , South San Francisco, CA, USA.
  • Sun Y; Antibody Engineering, Genentech Inc , South San Francisco, CA, USA.
  • Lin Z; Antibody Engineering, Genentech Inc , South San Francisco, CA, USA.
  • Schneider K; Antibody Engineering, Genentech Inc , South San Francisco, CA, USA.
  • Zhang P; Antibody Engineering, Genentech Inc , South San Francisco, CA, USA.
  • Vij R; Antibody Engineering, Genentech Inc , South San Francisco, CA, USA.
  • Sharpnack D; Departments of Biochemical and Cellular Pharmacology, Genentech Inc , South San Francisco, CA, USA.
  • Chan P; Departments of Biochemical and Cellular Pharmacology, Genentech Inc , South San Francisco, CA, USA.
  • de la Cruz C; Research biology, Genentech Inc , South San Francisco, CA, USA.
  • Sadowsky J; Protein Chemistry, Genentech Inc , South San Francisco, CA, USA.
  • Seshasayee D; Antibody Engineering, Genentech Inc , South San Francisco, CA, USA.
  • Koerber JT; Antibody Engineering, Genentech Inc , South San Francisco, CA, USA.
  • Pillow TH; Discovery Chemistry, Genentech Inc , South San Francisco, CA, USA.
  • Phillips GD; Research biology, Genentech Inc , South San Francisco, CA, USA.
  • Rowntree RK; Research biology, Genentech Inc , South San Francisco, CA, USA.
  • Boswell CA; Preclinical & Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc , South San Francisco, CA, USA.
  • Kozak KR; Departments of Biochemical and Cellular Pharmacology, Genentech Inc , South San Francisco, CA, USA.
  • Polson AG; Research biology, Genentech Inc , South San Francisco, CA, USA.
  • Polakis P; Research biology, Genentech Inc , South San Francisco, CA, USA.
  • Yu SF; Research biology, Genentech Inc , South San Francisco, CA, USA.
  • Dragovich PS; Discovery Chemistry, Genentech Inc , South San Francisco, CA, USA.
  • Agard NJ; Antibody Engineering, Genentech Inc , South San Francisco, CA, USA.
MAbs ; 13(1): 1862452, 2021.
Article em En | MEDLINE | ID: mdl-33382956
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Imunoconjugados / Ensaios Antitumorais Modelo de Xenoenxerto / Anticorpos Monoclonais / Antígenos de Superfície / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Imunoconjugados / Ensaios Antitumorais Modelo de Xenoenxerto / Anticorpos Monoclonais / Antígenos de Superfície / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article