Inhibitory effects of alkaline extract from the pericarp of Citrus reticulata Blanco on collagen behavior in bleomycin-induced pulmonary fibrosis.

Li, Ruo-Fei; Chen, Xin-Yue; Xu, Yong; Feng, Fan-Chao; He, Hai-Lang; Zhou, Xian-Mei

Li, Ruo-Fei; Chen, Xin-Yue; Xu, Yong; Feng, Fan-Chao; He, Hai-Lang; Zhou, Xian-Mei.

Afiliação

Li RF; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, PR China; The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China.
Chen XY; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, PR China; The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China.
Xu Y; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, PR China; Department of Respiratory and Critical Care Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, PR China.
Feng FC; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, PR China; Department of Respiratory and Critical Care Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, PR China.
He HL; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, PR China; Department of Respiratory and Critical Care Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, PR China.
Zhou XM; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, PR China; The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China; Department of Respiratory and Critical Care Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjin

J Ethnopharmacol ; 269: 113761, 2021 Apr 06.

Article em En | MEDLINE | ID: mdl-33383114

Assuntos

Citrus/química; Colágeno Tipo III/metabolismo; Colágeno Tipo I/metabolismo; Extratos Vegetais/farmacologia; Fibrose Pulmonar/tratamento farmacológico; Administração Oral; Álcalis/química; Aminoácido Oxirredutases/antagonistas & inibidores; Aminoácido Oxirredutases/metabolismo; Aminoácidos/metabolismo; Animais; Bleomicina/toxicidade; Colágeno Tipo III/genética; Modelos Animais de Doenças; Regulação para Baixo/efeitos dos fármacos; Proteínas da Matriz Extracelular/antagonistas & inibidores; Proteínas da Matriz Extracelular/metabolismo; Hidroxiprolina/metabolismo; Camundongos Endogâmicos C57BL; Extratos Vegetais/administração & dosagem; Proteína-Lisina 6-Oxidase/antagonistas & inibidores; Proteína-Lisina 6-Oxidase/metabolismo; Fibrose Pulmonar/induzido quimicamente; Fibrose Pulmonar/metabolismo; Fibrose Pulmonar/patologia; Proteína Smad3/genética; Fator de Crescimento Transformador beta1/genética

Palavras-chave

Citrus alkaline extract; Collagen crosslinking; Idiopathic pulmonary fibrosis; Lysyl oxidases; TGF-ß1/Smad3

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Extratos Vegetais / Citrus / Colágeno Tipo I / Colágeno Tipo III Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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