Generation of a novel decay accelerating factor (DAF) knock-out rat model using clustered regularly-interspaced short palindromic repeats, (CRISPR)/associated protein 9 (Cas9), genome editing.

Detsika, Maria G; Goudevenou, K; Geurts, A M; Gakiopoulou, H; Grapsa, E; Lianos, Elias A

Detsika, Maria G; Goudevenou, K; Geurts, A M; Gakiopoulou, H; Grapsa, E; Lianos, Elias A.

Afiliação

Detsika MG; 1st Department of Critical Care Medicine and Pulmonary Services, School of Medicine, Evangelismos Hospital, G.P. Livanos and M. Simou Laboratories, National and Kapodistrian University of Athens, 3 Ploutarchou Street, 10675, Athens, Greece. mdetsika@med.uoa.gr.
Goudevenou K; 1st Department of Critical Care Medicine and Pulmonary Services, School of Medicine, Evangelismos Hospital, G.P. Livanos and M. Simou Laboratories, National and Kapodistrian University of Athens, 3 Ploutarchou Street, 10675, Athens, Greece.
Geurts AM; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Gakiopoulou H; Department of Pathology, University of Athens School of Medicine, Athens, Greece.
Grapsa E; Department of Nephrology, School of Medicine, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Lianos EA; Veterans Affairs Medical Center and Virginia Tech. Carilion School of Medicine, 1970 Roanoke Blvd., Salem, VA, 24153, USA.

Transgenic Res ; 30(1): 11-21, 2021 02.

Article em En | MEDLINE | ID: mdl-33387103

Assuntos

Injúria Renal Aguda/genética; Antígenos CD55/genética; Ativação do Complemento/genética; Podócitos/metabolismo; Injúria Renal Aguda/patologia; Albuminúria; Animais; Anticorpos Anti-Idiotípicos/farmacologia; Antígenos CD55/deficiência; Antígenos CD55/imunologia; Sistemas CRISPR-Cas/genética; Ativação do Complemento/imunologia; Convertases de Complemento C3-C5/genética; Complemento C5/genética; Técnicas de Inativação de Genes; Complexo Antigênico da Nefrite de Heymann/genética; Complexo Antigênico da Nefrite de Heymann/imunologia; Humanos; Podócitos/patologia; Ratos

Palavras-chave

Anti-Fx1A; CRISPR; Complement; Decay accelerating factor (DAF)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação do Complemento / Antígenos CD55 / Podócitos / Injúria Renal Aguda Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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