Endometriosis and assisted reproductive techniques independently related to mother-child morbidities: a French longitudinal national study.
Reprod Biomed Online
; 42(3): 627-633, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-33388264
ABSTRACT
RESEARCH QUESTION Does endometriosis increase obstetric and neonatal complications, and does assisted reproductive technology (ART) cause additional risk of maternal or fetal morbidity? DESIGN:
A nationwide cohort study (2013-2018) comparing maternal and perinatal morbidities in three groups of single pregnancies spontaneous pregnancies without endometriosis; spontaneous pregnancies with endometriosis; and ART pregnancies in women with endometriosis.RESULTS:
Mean maternal ages were 30.0 (SDâ¯=â¯5.3), 31.7 (SDâ¯=â¯4.8) and 33.1 years (SDâ¯=â¯4.0), for spontaneous conceptions, spontaneous conceptions with endometriosis and ART pregnancies with endometriosis groups, respectively (P < 0.0001). Comparison of spontaneous conceptions with endometriosis and spontaneous conceptions endometriosis independently increased the risk of venous thrombosis (adjusted OR [aOR] 1.51, P < 0.001), pre-eclampsia (aOR 1.29, P < 0.001), placenta previa (aOR 2.62, P < 0.001), placental abruption (aOR 1.54, P < 0.001), premature birth (aOR 1.37, P < 0.001), small for gestational age (aOR 1.05, P < 0.001) and malformations (aOR 1.06, Pâ¯=â¯0.049). Comparison of ART pregnancies with endometriosis and spontaneous conceptions with endometriosis ART increased the risk of placenta previa (aOR 2.43, 95% CI 2.10 to 2.82, P < 0.001), premature birth (aOR 1.42, 95% CI 1.29 to 1.55, P < 0.001) and small for gestational age (aOR 1.18, 95% CI 1.10 to 1.27, P < 0.001), independently from the effect of endometriosis. Risk of pre-eclampsia, placental abruption or congenital malformations was not increased with ART.CONCLUSION:
Endometriosis is an independent risk factor for mother and child morbidities. Maternal morbidity and perinatal morbidity were significantly increased by ART in addition to endometriosis; however, some perinatal and maternal morbidity risks were increasingly linked to pathologies related to infertility.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Técnicas de Reprodução Assistida
/
Endometriose
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
/
Newborn
/
Pregnancy
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article