Associations of low-carbohydrate and low-fat intakes with all-cause mortality in subjects with prediabetes with and without insulin resistance.
Clin Nutr
; 40(5): 3601-3607, 2021 05.
Article
em En
| MEDLINE
| ID: mdl-33390277
ABSTRACT
BACKGROUND & AIMS:
We investigated the associations of low-carbohydrate and low-fat diets with all-cause mortality in people with prediabetes according to insulin resistance status using data from the National Health and Nutrition Examination Survey (NHANES).METHODS:
We analyzed the NHANES participants with prediabetes from 2005 to 2008, and their vital status was linked to the National Death Index through the end of 2011. Low-carbohydrate and low-fat diets were defined as â¦40% and â¦30% of calories from carbohydrate and fat, respectively. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to determine insulin resistance. Weighted Cox proportional hazards regression models were used to compare the hazard ratios for the associations of low-carbohydrate and low-fat diets with all-cause mortality.RESULTS:
Among the 1687 participants with prediabetes, 96 of them had died after a median follow-up of 4.5 years. Participants with a HOMA-IR >3.0 had an increase in all-cause mortality compared with those who had a HOMA-IR â¦3.0 (HR 1.797, 95% CI 1.110 to 2.909, p = 0.019). Participants with â¦40% of calories from carbohydrate and >30% from fat (3.75 per 1000 person-years) had a lower all-cause mortality rate compared with those who had >40% from carbohydrate and >30% from fat (10.20 per 1000 person-years) or >40% from carbohydrate and â¦30% from fat (8.09 per 1000 person-years), with statistical significance observed in those who had a HOMA-IR â¦3.0.CONCLUSIONS:
A low-carbohydrate intake (â¦40%) was associated with a lower all-cause mortality rate in people with prediabetes.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estado Pré-Diabético
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Resistência à Insulina
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Dieta com Restrição de Gorduras
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Dieta com Restrição de Carboidratos
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article