DNA-protein crosslink proteases in genome stability.
Commun Biol
; 4(1): 11, 2021 01 04.
Article
em En
| MEDLINE
| ID: mdl-33398053
ABSTRACT
Proteins covalently attached to DNA, also known as DNA-protein crosslinks (DPCs), are common and bulky DNA lesions that interfere with DNA replication, repair, transcription and recombination. Research in the past several years indicates that cells possess dedicated enzymes, known as DPC proteases, which digest the protein component of a DPC. Interestingly, DPC proteases also play a role in proteolysis beside DPC repair, such as in degrading excess histones during DNA replication or controlling DNA replication checkpoints. Here, we discuss the importance of DPC proteases in DNA replication, genome stability and their direct link to human diseases and cancer therapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Instabilidade Genômica
/
Proteínas de Ligação a DNA
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article