Rapid access to Asp/Glu sidechain hydrazides as thioester precursors for peptide cyclization and glycosylation.
Chem Commun (Camb)
; 57(8): 1006-1009, 2021 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-33399597
ABSTRACT
Head-to-sidechain macrocylic peptides, and neoglycopeptides, were readily prepared by site-specific amidation of aspartic and glutamic acid sidechain hydrazides. Hydrazides, serving as latent thioesters, were introduced through regioselective opening of the corresponding Nα-Fmoc protected anhydride precursors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
/
Ácido Aspártico
/
Ácido Glutâmico
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article