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Rapid access to Asp/Glu sidechain hydrazides as thioester precursors for peptide cyclization and glycosylation.
Barnes, Natalie G; Nyandoro, Kudakwashe; Jin, Hanzhang; Macmillan, Derek.
Afiliação
  • Barnes NG; Department of Chemistry, University College London, 20 Gordon Street, London, WC1H0AJ, UK. d.macmillan@ucl.ac.uk.
  • Nyandoro K; Department of Chemistry, University College London, 20 Gordon Street, London, WC1H0AJ, UK. d.macmillan@ucl.ac.uk.
  • Jin H; Department of Chemistry, University College London, 20 Gordon Street, London, WC1H0AJ, UK. d.macmillan@ucl.ac.uk.
  • Macmillan D; Department of Chemistry, University College London, 20 Gordon Street, London, WC1H0AJ, UK. d.macmillan@ucl.ac.uk.
Chem Commun (Camb) ; 57(8): 1006-1009, 2021 Feb 01.
Article em En | MEDLINE | ID: mdl-33399597
ABSTRACT
Head-to-sidechain macrocylic peptides, and neoglycopeptides, were readily prepared by site-specific amidation of aspartic and glutamic acid sidechain hydrazides. Hydrazides, serving as latent thioesters, were introduced through regioselective opening of the corresponding Nα-Fmoc protected anhydride precursors.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Ácido Aspártico / Ácido Glutâmico Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Ácido Aspártico / Ácido Glutâmico Idioma: En Ano de publicação: 2021 Tipo de documento: Article