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Two new sesquiterpenes from the rhizomes of Atractylodes macrocephala and their biological activities.
Zhao, Yi-Nan; Gao, Gai; Ma, Jin-Lian; Xu, Rui-Zhu; Guo, Tao; Wu, Li-Min; Liu, Xin-Guang; Xie, Zhi-Shen; Xu, Jiang-Yan; Zhang, Zhen-Qiang; Wang, Pan.
Afiliação
  • Zhao YN; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.
  • Gao G; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.
  • Ma JL; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.
  • Xu RZ; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.
  • Guo T; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
  • Wu LM; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.
  • Liu XG; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.
  • Xie ZS; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.
  • Xu JY; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.
  • Zhang ZQ; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.
  • Wang P; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China.
Nat Prod Res ; 36(5): 1230-1235, 2022 Mar.
Article em En | MEDLINE | ID: mdl-33401972
ABSTRACT
Two new sesquiterpenes, named selina-4(14),7,11-trien-9-ol (1) and selina-4(14),11-dien-7-ol (2), along with two known compounds were isolated from rhizomes of Atractylodes macrocephala Koidz. All structures were assigned on the basis of detailed spectroscopic analyses. The absolute configuration of 1 was established by TDDFT-ECD calculations. Compound 1 was found to moderately inhibit LSD1 activity with IC50 value of 34.0 µM. Compounds 1 and 4 exhibited a regulate effect on Keap1-Nrf2-ARE pathway.[Formula see text].
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Atractylodes Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Atractylodes Idioma: En Ano de publicação: 2022 Tipo de documento: Article