Two new sesquiterpenes from the rhizomes of Atractylodes macrocephala and their biological activities.
Nat Prod Res
; 36(5): 1230-1235, 2022 Mar.
Article
em En
| MEDLINE
| ID: mdl-33401972
ABSTRACT
Two new sesquiterpenes, named selina-4(14),7,11-trien-9-ol (1) and selina-4(14),11-dien-7-ol (2), along with two known compounds were isolated from rhizomes of Atractylodes macrocephala Koidz. All structures were assigned on the basis of detailed spectroscopic analyses. The absolute configuration of 1 was established by TDDFT-ECD calculations. Compound 1 was found to moderately inhibit LSD1 activity with IC50 value of 34.0 µM. Compounds 1 and 4 exhibited a regulate effect on Keap1-Nrf2-ARE pathway.[Formula see text].
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Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Atractylodes
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article