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NT157, an IGF1R-IRS1/2 inhibitor, exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia.
Scopim-Ribeiro, Renata; Machado-Neto, João Agostinho; Eide, Christopher A; Coelho-Silva, Juan Luiz; Fenerich, Bruna Alves; Fernandes, Jaqueline Cristina; Scheucher, Priscila Santos; Savage Stevens, Samantha L; de Melo Campos, Paula; Olalla Saad, Sara T; de Carvalho Palma, Leonardo; de Figueiredo-Pontes, Lorena Lobo; Simões, Belinda Pinto; Rego, Eduardo Magalhães; Tognon, Cristina E; Druker, Brian J; Traina, Fabiola.
Afiliação
  • Scopim-Ribeiro R; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirante 3900, Ribeirão Preto, São Paulo, Brazil.
  • Machado-Neto JA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
  • Eide CA; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirante 3900, Ribeirão Preto, São Paulo, Brazil.
  • Coelho-Silva JL; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Fenerich BA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
  • Fernandes JC; Howard Hughes Medical Institute, Portland, OR, USA.
  • Scheucher PS; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirante 3900, Ribeirão Preto, São Paulo, Brazil.
  • Savage Stevens SL; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirante 3900, Ribeirão Preto, São Paulo, Brazil.
  • de Melo Campos P; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirante 3900, Ribeirão Preto, São Paulo, Brazil.
  • Olalla Saad ST; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirante 3900, Ribeirão Preto, São Paulo, Brazil.
  • de Carvalho Palma L; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
  • de Figueiredo-Pontes LL; Hematology and Transfusion Medicine Center, University of Campinas/Hemocentro UNICAMP, Campinas, São Paulo, Brazil.
  • Simões BP; Hematology and Transfusion Medicine Center, University of Campinas/Hemocentro UNICAMP, Campinas, São Paulo, Brazil.
  • Rego EM; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirante 3900, Ribeirão Preto, São Paulo, Brazil.
  • Tognon CE; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirante 3900, Ribeirão Preto, São Paulo, Brazil.
  • Druker BJ; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirante 3900, Ribeirão Preto, São Paulo, Brazil.
  • Traina F; Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirante 3900, Ribeirão Preto, São Paulo, Brazil.
Invest New Drugs ; 39(3): 736-746, 2021 06.
Article em En | MEDLINE | ID: mdl-33403501
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirogalol / Sulfonamidas / Leucemia Mielogênica Crônica BCR-ABL Positiva / Receptor IGF Tipo 1 / Inibidores de Proteínas Quinases / Proteínas Substratos do Receptor de Insulina / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirogalol / Sulfonamidas / Leucemia Mielogênica Crônica BCR-ABL Positiva / Receptor IGF Tipo 1 / Inibidores de Proteínas Quinases / Proteínas Substratos do Receptor de Insulina / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article