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Albumin-to-globulin ratio (AGR) as a potential marker of predicting lupus nephritis in Chinese patients with systemic lupus erythematosus.
Liu, Xin-Ran; Qi, Yuan-Yuan; Zhao, Ya-Fei; Cui, Yan; Wang, Xiao-Yang; Zhao, Zhan-Zheng.
Afiliação
  • Liu XR; Nephrology Hospital, The First Affiliated Hospital of Zhengzhou University, Henan, China.
  • Qi YY; Institute of Nephrology, Zhengzhou University, Henan, China.
  • Zhao YF; Nephrology Hospital, The First Affiliated Hospital of Zhengzhou University, Henan, China.
  • Cui Y; Institute of Nephrology, Zhengzhou University, Henan, China.
  • Wang XY; Nephrology Hospital, The First Affiliated Hospital of Zhengzhou University, Henan, China.
  • Zhao ZZ; Institute of Nephrology, Zhengzhou University, Henan, China.
Lupus ; 30(3): 412-420, 2021 Mar.
Article em En | MEDLINE | ID: mdl-33407045
OBJECTIVES: To evaluate a potential role of albumin-to-globulin ratio (AGR) in the development of lupus nephritis (LN) and determine the potential to use AGR as a marker for future LN in systemic lupus erythematosus (SLE) patients. METHODS: 194 newly diagnosed SLE patients without renal impairment were followed. The clinical data were collected and analyzed at the time of initial diagnosis of SLE and the end of follow-up. We compared baseline characteristics between those who did or did not develop LN on follow-up. Univariate and multivariate Cox hazard analysis were used to identify predictors of lupus nephritis. RESULTS: Among the 194 newly diagnosed SLE patients without renal impairment, 26 (13.40%) patients were diagnosed with LN during a median follow-up of 53.87 months. On univariate Cox analysis, patients with the history of alopecia, higher SBP, lower AGR, lower CRP, lower C3, lower C4, higher anti-dsDNA Ab, presence of ANA homogeneous patterns or higher SLEDAI had an increased probability of developing LN. In a multivariate model, the history of alopecia (adjust hazard ratio, aHR = 3.614, 95%CI 1.365-9.571 P = 0.010), lower AGR (aHR = 6.968, 95%CI 1.873-25.919, P = 0.004), lower CRP (aHR = 4.230, 95%CI 1.591-11.247, P = 0.004) and higher level of anti-dsDNA (aHR = 2.675, 95%CI 1.008-7.093, P = 0.048) were independently associated with an increased risk of developing LN after adjusting for covariates. CONCLUSION: Our findings indicated that SLE patients with low AGR, low CRP, high anti-dsDNA and the history of alopecia were more likely to develop LN in the course of SLE. AGR shown the greatest hazard for developing LN among them, it may be a strong predictor.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nefrite Lúpica / Albumina Sérica / Soroglobulinas Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País como assunto: Asia Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nefrite Lúpica / Albumina Sérica / Soroglobulinas Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País como assunto: Asia Idioma: En Ano de publicação: 2021 Tipo de documento: Article