Use of Plasma Metagenomic Next-generation Sequencing for Pathogen Identification in Pediatric Endocarditis.
Pediatr Infect Dis J
; 40(5): 486-488, 2021 05 01.
Article
em En
| MEDLINE
| ID: mdl-33410648
ABSTRACT
Pediatric infective endocarditis incurs significant morbidity and generally occurs among children with underlying heart disease. Identification of a pathogen is critical in determining appropriate therapy. However, standard diagnostic testing has limited sensitivity. We describe a case series of children with infective endocarditis in whom plasma next-generation sequencing (Karius, Redwood, CA) identified an organism in 8 of 10 cases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plasma
/
Endocardite
/
Metagenoma
/
Ácidos Nucleicos Livres
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article